The election follows the resignation of Conservative MP Owen Paterson, who was found to have breached parliamentary rules on lobbying.
Dr Neil Shastri-Hurst was selected as the Conservative candidate on Saturday and Kirsty Walmsley has been chosen to represent the Reform UK party.
Dr Shastri-Hurst would appear to be the favourite in the December 16 by-election with Mr Paterson having secured a 23,000 majority at the last General Election, while the seat has been Conservative for more than 100 years.
The by-election is set to take place on 16 December, with the Liberal Democrats and the Green party expected to announce their candidates shortly.
Presumably, Conservatives will hold.