I’m pleased to say you’ve got it Devo…
Over to you.
Thanks. Easy one,(I think):
Red medicine.
Think we might need a clue here Devo…
The clue is just two synonyms.
The film was the first by a well known film-making partnership.
Blood Shot?
You’re getting there. The second word is quite archaic in the context of the clue but not completely forgotten.
Blood and Wine?
No, the answer is two words.
The star married the writer/director the same year as the film eas released and they are still married.
Blood Simple was the very first one I thought of because of the Coen Brothers but I don’t get how that relates to medication?
I’ve heard of ‘simple’ used to mean a medicine…A little less obscure ,please.
It is Blood Simple and what’s wrong with a bit of obscurity as long as it is not too obscure and I don’t think that use of ‘simple’ is - I knew it without looking it up.
Mental note to use dictionary.com for synonyms - it did have that included but whatever I used to check “simple” didn’t.
Next clue:
George the First leads Douglas the Conquerer in stages.
If you get who Douglas is you get the clue. Funnily enough he’s recently come back into the news…
This particular conquest took place 30 years ago in Tokyo…
Falling down
No sorry Feey but you might have got the right event…
G Host Buster (s)
Correct Arena G host(Buster)s. 
Over to you…
Start cooking with less fat